Article

Rapid cyclic stretching induces a synthetic, proinflammatory phenotype in cultured human intestinal smooth muscle, with the potential to alter signaling to adjacent bowel cells

2024-10-15

Abstract excerpt

<h4>Background and Aims</h4> Bowel smooth muscle experiences mechanical stress constantly during normal function, and pathologic mechanical stressors in disease states. We tested the hypothesis that pathologic mechanical stress could alter transcription to induce smooth muscle phenotypic class switching. <h4>Methods</h4> Primary human intestinal smooth muscle cells (HISMCs), seeded on electrospun aligned poly-ε-...

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Literature Corpus work: 62bf62cc-77f7-5907-a4a2-5066f9f16d1a
DOI: 10.1101/2024.10.12.617767

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