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Article

High throughput interrogation of human liver stellate cells reveals microenvironmental regulation of phenotype.

Acta biomaterialia - 15 Jan 2022

Brougham-Cook Aidan, Jain Ishita, Kukla David A, Masood Faisal, Kimmel Hannah, Ryoo Hyeon, Khetani Salman R, Underhill Gregory H

Abstract excerpt

Liver fibrosis is a common feature of progressive liver disease and is manifested as a dynamic series of alterations in both the biochemical and biophysical properties of the liver. Hepatic stellate cells (HSCs) reside within the perisinusoidal space of the liver sinusoid and are one of the main drivers of liver fibrosis, yet it remains unclear how changes to the sinusoidal microenvironment impact HSC phenotype...

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Identifiers

PMID: 34800715
DOI: 10.1016/j.actbio.2021.11.015
PMCID: PMC8738161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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