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Article

Inducing endoderm differentiation by modulating mechanical properties of soft substrates.

Journal of tissue engineering and regenerative medicine - 1 Jan 2015

Jaramillo Maria, Singh Satish S, Velankar Sachin, Kumta Prashant N, Banerjee Ipsita

Abstract excerpt

Early embryonic stem cell (ESC) differentiation is marked by the formation of three germ layers from which all tissues types arise. Conventionally, ESCs are differentiated by altering their chemical microenvironment. Recently however, it was established that a mechanical microenvironment can also contribute towards cellular phenotype commitment. In this study, we report how the cellular mechanical...

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Identifiers

PMID: 23008262
DOI: 10.1002/term.1602
PMCID: PMC4130804

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