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Article

Modulation of human iPSC-derived hepatocyte phenotype via extracellular matrix microarrays.

Acta biomaterialia - 1 Nov 2022

Monckton Chase P, Brougham-Cook Aidan, Underhill Gregory H, Khetani Salman R

Abstract excerpt

In vitro human liver models are essential for drug screening, disease modeling, and cell-based therapies. Induced pluripotent stem cell (iPSC)-derived hepatocyte-like cells (iHeps) mitigate sourcing limitations of primary human hepatocytes (PHHs) and enable precision medicine; however, current protocols yield iHeps with very low differentiated functions. The composition and stiffness of liver's extracellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36115650
DOI: 10.1016/j.actbio.2022.09.013
PMCID: PMC9869484

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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