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Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal

2 Nov 2022

Abstract excerpt

Abstract Intestinal organoids, derived from intestinal stem cell self-organization, recapitulate the tissue structures and behaviors of the intestinal epithelium, which hold great potential for the study of developmental biology, disease modeling, and regenerative medicine. The intestinal epithelium is exposed to dynamic mechanical forces which exert profound effects on gut development. However, the conventional...

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PMID: 36319799
DOI: 10.1186/s13619-022-00137-4

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