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Article

Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality

1 Mar 2021

Abstract excerpt

Tumor-associated macrophages (TAMs) play an important role in tumor immunity and comprise of subsets that have distinct phenotype, function, and ontology. Transcriptomic analyses of human medulloblastoma, the most common malignant pediatric brain cancer, showed that medulloblastomas (MBs) with activated sonic hedgehog signaling (SHH-MB) have significantly more TAMs than other MB subtypes. Therefore, we examined...

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PMID: 33789113
DOI: 10.1016/j.celrep.2021.108917

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