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Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia Activation

2022-04-20

Abstract excerpt

Malignant gliomas commandeer an abundant inflammatory infiltrate with glioma-associated macrophages and microglia (GAMM) actively promoting tumor progression. Like all cells in the mononuclear phagocytic system, macrophages and microglia constitutively express the poliovirus receptor, CD155. Besides myeloid cells, CD155 is widely upregulated ectopically in the neoplastic compartment of malignant gliomas (and solid...

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Literature Corpus work
e525c9b5-e9e5-58cf-b37e-c817ac9a54b4
DOI
10.1101/2022.04.19.488771
Open publication

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Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia ActivationDOI 10.1101/2022.04.19.488771
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