Article

Therapeutic efficacy of an immune stimulatory gene therapy strategy in a mouse model of high grade brainstem glioma

2019-11-18

Abstract excerpt

<h4>Purpose</h4> Diffuse intrinsic pontine glioma (DIPG) bears a dismal prognosis. A genetically engineered brainstem glioma model harboring the recurrent DIPG mutation, ACVR1-G328V (mACVR1), was developed for testing an immune-stimulatory gene therapy. <h4>Experimental Design</h4> We utilized the Sleeping Beauty transposase system to generate an endogenous mouse model of mACVR1 brainstem glioma. Histology was u...

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Literature Corpus work: 4df82c4c-9491-5c61-af0b-aeb3292f2c7e
DOI: 10.1101/846097

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