Article

High cRel-expressing germinal center B cells favor precursor plasma cell generation

2026-04-29

Abstract excerpt

Germinal centers (GCs) are the site of antibody affinity maturation by the process of somatic hypermutation (SHM) and produce long-lived plasma cells (PCs). GC B cells circulate between two distinct zones: the light zone (LZ) and the dark zone (DZ). It has been demonstrated that the transcription factor NFκB cRel is required for B cell proliferation and GC B cell maintenance. cRel-deleted GC B cells show reduced S...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dad54fcf-612d-53f0-ae37-8a7e03271baa
DOI: 10.64898/2026.04.26.720943

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High cRel-expressing germinal center B cells favor precursor plasma cell generationDOI 10.64898/2026.04.26.720943Read

Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcomeSemantic proximity Read

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopesSemantic proximity Read

PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transitionSemantic proximity Read

Single cell clonal analysis identifies an AID-dependent pathway of plasma cell differentiationSemantic proximity Read

A Germinal Center–Independent Innate-Like Memory B Cell Compartment of B1 OriginSemantic proximity Read

Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.Semantic proximity Read

Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting.Semantic proximity Read

Complex subsets but redundant clonality after B cells egress from spontaneous germinal centersSemantic proximity Read

Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.Semantic proximity Read

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.Semantic proximity Read

High-resolution single-cell atlas of the human B cell compartment and immune microenvironment across tissuesSemantic proximity Read

Germinal center-dependent and -independent memory B cells produced throughout the immune response.Semantic proximity Read