Article

Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses

2021-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency, is characterized by impaired terminal B-cell differentiation and defective antibody responses. Incomplete genetic penetrance and a wide range of phenotypic expressivity in CVID suggest the participation of additional pathogenic mechanisms. Monozygotic (MZ) twins discordant for CVID are uniquely valu...

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Literature Corpus work: 1a61ba8c-da8a-5366-a463-2537d0c235a7
DOI: 10.1101/2021.12.20.473453

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