Article

Engineering of human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia and solid tumor metastasis

2021-09-11

Abstract excerpt

The bone marrow microenvironment provides indispensable factors to sustain blood production throughout life. It is also a hotspot for the progression of hematologic disorders and the most frequent site of solid tumor metastasis. Pre-clinical research relies on xenograft mouse models, precluding the human-specific functional interactions of stem cells with their bone marrow microenvironment. Human mesenchymal cells...

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Literature Corpus work: 9d714103-7772-5362-9b64-f16fdd8be45a
DOI: 10.1101/2021.09.11.459806

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