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In vitro biomimetic engineering of a human hematopoietic niche with functional properties

4 Jun 2018

Abstract excerpt

In adults, human hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow (BM) microenvironment. Our understanding of human hematopoiesis and the associated niche biology remains limited, due to human material accessibility and limits of existing in vitro culture models. The establishment of an in vitro BM system would offer an experimentally accessible and tunable platform to study human...

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PMID: 29866839
DOI: 10.1073/pnas.1805440115

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