Article

Integration of Hematopoietic and Thymus-like Niches in a Human iPSC-derived Bone Marrow Organoid

2025-11-06

Abstract excerpt

Human bone marrow generates blood cells but critically lacks the thymic environment required for T cell development. Developing an integrated in vitro platform that reconstitutes both functions simultaneously remains a major challenge in regenerative and immune medicine. We asked whether a synthetic marrow could be engineered to provide both capacities. Using human induced pluripotent stem cells, we created self-o...

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Literature Corpus work: 7410f21e-44b2-51e1-a1dc-3655503cb293
DOI: 10.1101/2025.11.04.686649

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