Article

comBO: A combined human bone and lympho-myeloid bone marrow organoid for pre-clinical modelling of haematopoietic disorders

2025-02-17

Abstract excerpt

The bone marrow supports lifelong blood and immune cell production. Current human bone marrow organoid models do not include both lymphoid and myeloid elements and lack the complexity of stromal cell types present in native haematopoietic tissues, precluding the accurate ex vivo modelling of human pathologies. Here we introduce “comBOs” ( com bined b one and lympho-myeloid bone marrow o rganoids) that include...

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Literature Corpus work: b6c6364f-aade-5a88-a02f-1bc69a9082fe
DOI: 10.1101/2025.02.16.638505

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