Article

Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies

2022-03-16

Abstract excerpt

A lack of models that recapitulate the complexity of human bone marrow has hampered mechanistic studies of normal and malignant hematopoiesis and the validation of novel therapies. Here, we describe a step-wise, directed-differentiation protocol in which organoids are generated from iPSCs committed to mesenchymal, endothelial and hematopoietic lineages. These 3-dimensional structures capture key features of human...

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Literature Corpus work: b3aad656-ede4-52c8-b5cd-7bbbd4461371
DOI: 10.1101/2022.03.14.483815

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