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Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches

16 Feb 2018

Abstract excerpt

Xenotransplantation of patient-derived samples in mouse models has been instrumental in depicting the role of hematopoietic stem and progenitor cells in the establishment as well as progression of hematological malignancies. The foundations for this field of research have been based on the development of immunodeficient mouse models, which provide normal and malignant human hematopoietic cells with a supportive...

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PMID: 29453226
DOI: 10.1084/jem.20172139

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