Article

Humanized <i>in vivo</i> bone marrow models orchestrate multi-lineage human hematopoietic cell development

2024-04-11

Abstract excerpt

Hematopoiesis develops in the bone marrow (BM) where multiple interactions regulate differentiation and preservation of hematopoietic stem/progenitor cells (HSPCs). Although murine BM has been extensively analyzed, the human BM microenvironment remains less understood. Immune-deficient murine models have enabled the analysis of molecular and cellular regulation of human HSPCs, which remains limited as human hemato...

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Literature Corpus work: 1817ba0e-3848-5065-aa1b-75b102b9f777
DOI: 10.1101/2024.04.08.588553

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