Article
Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches.
Blood - 22 Dec 2016
Antonelli Antonella, Noort Willy A, Jaques Jenny, de Boer Bauke, de Jong-Korlaar Regina, Brouwers-Vos Annet Z, Lubbers-Aalders Linda, van Velzen Jeroen F, Bloem Andries C, Yuan Huipin, de Bruijn Joost D, Ossenkoppele Gert J, Martens Anton C M, Vellenga Edo, Groen Richard W J, Schuringa Jan Jacob
Abstract excerpt
To begin to understand the mechanisms that regulate self-renewal, differentiation, and transformation of human hematopoietic stem cells or to evaluate the efficacy of novel treatment modalities, stem cells need to be studied in their own species-specific microenvironment. By implanting ceramic scaffolds coated with human mesenchymal stromal cells into immune-deficient mice, we were able to mimic the human bone...
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