Article

Nucleolar endonuclease MBLAC2 orchestrates co-transcriptional ribosomal RNA processing and global transcriptional output

2026-08-03

Abstract excerpt

<h4>Summary</h4> The metallo-β-lactamase (MBL)-domain superfamily includes multiple nucleases that process distinct transcript classes. We show that human MBLAC2 acts as a ribosomal (r)RNA quality control factor, being nucleolar specific, chromatin-associated and required for co-transcriptional pre-rRNA processing. Notably MBLAC2 is functionally distinct from other MBL containing proteins, being required for main...

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Literature Corpus work: 9d2420e1-3a03-532b-b5e1-a55f9c8ee475
DOI: 10.64898/2026.07.31.742021

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