Article

Eukaryotic tRNA ligases mediate RNA break repair

2026-05-27

Abstract excerpt

<h4>SUMMARY</h4> RNA is continuously exposed to damage during physiological metabolism and stress, yet cellular responses to RNA damage remain less understood than DNA repair pathways. RNA strand breaks are particularly deleterious because they generate chemically incompatible RNA ends. Eukaryotic tRNA ligases have been implicated in RNA processing and repair, but whether they function as general RNA repair enzym...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9609045c-0d66-56ca-9e31-9fd7354c02c7
DOI: 10.64898/2026.05.26.727988

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Eukaryotic tRNA ligases mediate RNA break repairDOI 10.64898/2026.05.26.727988Read

Different alterations in mRNP composition trigger an increase in harmful R-loopsSemantic proximity Read

Coordination of transcription-coupled repair and repair-independent release of stalled RNA polymerase II in response to transcription-blocking lesionsSemantic proximity Read

Structural framework for the assembly of the human tRNA ligase complexSemantic proximity Read

Nucleolar endonuclease MBLAC2 orchestrates co-transcriptional ribosomal RNA processing and global transcriptional outputSemantic proximity Read

RNA degradation by DIS3 is a necessary step in the resolution of backtracked transcription complexesSemantic proximity Read

RNA Transcripts Serve as a Template for Double-Strand Break Repair in Human CellsSemantic proximity Read

Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1.Semantic proximity Read

Biochemical and structural insights into a 5’ to 3’ RNA ligase reveal a potential role in tRNA ligationSemantic proximity Read

Telomerase RNA processing: Implications for human health and diseaseSemantic proximity Read

DNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes.Semantic proximity Read

A <i>POLR3B</i> -variant reveals a Pol III transcriptome response dependent on La protein/SSBSemantic proximity Read

tModBase: deciphering the landscape of tRNA modifications and their dynamic changes from epitranscriptome dataSemantic proximity Read