Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair

3 Jun 2019

Abstract excerpt

The nucleolus is a nuclear sub-domain containing the most highly transcribed genes in the genome. Hundreds of human ribosomal RNA (rRNA) genes, located in the nucleolus, rely on constant maintenance. DNA double-strand breaks (DSBs) in rRNA genes activate the ATM kinase, repress rRNA transcription and induce nucleolar cap formation. Yet how ribosomal-DNA (rDNA) lesions are detected and processed remains elusive....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Cytomegalovirus and herpesvirus research
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31184714
DOI: 10.1093/nar/gkz518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repairPMID 31184714Read ↗

Recent advances in the nucleolar responses to DNA double-strand breaksSemantic proximity Read ↗

Nucleolar responses to DNA double-strand breaksSemantic proximity Read ↗

RNA Polymerase II-mediated transcription is required for repair of ribosomal DNA breaks in nucleolar caps, guarding against genomic instabilitySemantic proximity Read ↗

JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damageSemantic proximity Read ↗

Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage responseSemantic proximity Read ↗

The Nucleolus: In Genome Maintenance and Repair.Semantic proximity Read ↗

Protein UFMylation regulates early events of ribosomal DNA double-stranded break responseSemantic proximity Read ↗

Treacle Sticks the Nucleolar Responses to DNA Damage TogetherSemantic proximity Read ↗

Hyper-recombination in ribosomal DNA is driven by resection-independent RAD51 loadingSemantic proximity Read ↗

The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and RepairSemantic proximity Read ↗

Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartmentsSemantic proximity Read ↗

RIG-I-like receptors sense replication stress through ribosomal DNA integrity to drive inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.