Article

<i>In vivo</i> single-cell CRISPR screening for microproteins identifies a critical ribosomal component

2025-03-17

Abstract excerpt

The dark proteome includes a rapidly expanding catalog of microproteins with unknown functions that have been historically ignored in genome annotations. Here, we exploit an in vivo single-cell CRISPR screening strategy in the mouse epidermis to systematically investigate the tissue-wide function of microproteins. We document the global and cell-type-specific roles of microproteins during epidermal development an...

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Identifiers and source

Literature Corpus work: cb596f59-de01-575d-b1ca-953321b000e0
DOI: 10.1101/2025.03.17.643322

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