Article

Mapping native R-loops genome-wide using a targeted nuclease approach

2018-10-30

Abstract excerpt

R-loops are three-stranded DNA:RNA hybrids that are pervasive in the eukaryotic and prokaryotic genomes and have been implicated in a variety of nuclear processes, including transcription, replication, DNA repair, and chromosome segregation. While R-loops may have physiological roles, the formation of stable, aberrant R-loops has been observed in disease, particularly neurological disorders and cancer. Despite the...

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Literature Corpus work: ee7f98ad-7816-5aa3-908b-bc3080f56de8
DOI: 10.1101/457226

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