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Article

The distribution of common-variant effect sizes.

Nature genetics - 1 Aug 2021

O'Connor Luke J

Abstract excerpt

The genetic effect-size distribution of a disease describes the number of risk variants, the range of their effect sizes and sample sizes that will be required to discover them. Accurate estimation has been a challenge. Here I propose Fourier Mixture Regression (FMR), validating that it accurately estimates real and simulated effect-size distributions. Applied to summary statistics for ten diseases (average...

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PMID: 34326547
DOI: 10.1038/s41588-021-00901-3

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