SNP-based heritability and selection analyses: Improved models and new results.

doi:10.1002/bies.202100170

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Article

SNP-based heritability and selection analyses: Improved models and new results.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 May 2022

Speed Doug, Kaphle Anubhav, Balding David J

Abstract excerpt

Complex-trait genetics has advanced dramatically through methods to estimate the heritability tagged by SNPs, both genome-wide and in genomic regions of interest such as those defined by functional annotations. The models underlying many of these analyses are inadequate, and consequently many SNP-heritability results published to date are inaccurate. Here, we review the modelling issues, both for analyses based...

Topics

Gene Frequency
Genome, Human
Genome-Wide Association Study
Genotype
Humans
Models, Genetic
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait, Heritable

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PMID: 35279859
DOI: 10.1002/bies.202100170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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