Article
Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.
Nature genetics - 1 May 2018
Evans Luke M, Tahmasbi Rasool, Vrieze Scott I, Abecasis Gonçalo R, Das Sayantan, Gazal Steven, Bjelland Douglas W, de Candia Teresa R, Goddard Michael E, Neale Benjamin M, Yang Jian, Visscher Peter M, Keller Matthew C
Abstract excerpt
Multiple methods have been developed to estimate narrow-sense heritability, h2, using single nucleotide polymorphisms (SNPs) in unrelated individuals. However, a comprehensive evaluation of these methods has not yet been performed, leading to confusion and discrepancy in the literature. We present the most thorough and realistic comparison of these methods to date. We used thousands of real whole-genome sequences...
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