Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data.

American journal of human genetics - 7 Jul 2016

Shi Huwenbo, Kichaev Gleb, Pasaniuc Bogdan

Abstract excerpt

Variance-component methods that estimate the aggregate contribution of large sets of variants to the heritability of complex traits have yielded important insights into the genetic architecture of common diseases. Here, we introduce methods that estimate the total trait variance explained by the typed variants at a single locus in the genome (local SNP heritability) from genome-wide association study (GWAS)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Datasets as Topic
Share to Genetic Predisposition to Disease
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to Models, Genetic

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 27346688
DOI: 10.1016/j.ajhg.2016.05.013
PMCID: PMC5005444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data.PMID 27346688Read ↗

Contrasting the genetic architecture of 30 complex traits from summary association dataSemantic proximity Read ↗

Dissecting the genetics of complex traits using summary association statisticsSemantic proximity Read ↗

Dissecting the genetics of complex traits using summary association statistics.Semantic proximity Read ↗

Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits.Semantic proximity Read ↗

Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data.Semantic proximity Read ↗

GWAShug: a comprehensive platform for decoding the shared genetic basis between complex traits based on summary statistics.Semantic proximity Read ↗

Dissecting the high-resolution genetic architecture of complex phenotypes by accurately estimating gene-based conditional heritability.Semantic proximity Read ↗

The PAGE Study: How Genetic Diversity Improves Our Understanding of the Architecture of Complex TraitsSemantic proximity Read ↗

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits and implications for the futureSemantic proximity Read ↗

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits.Semantic proximity Read ↗

Genome-wide complex trait analysis (GCTA): methods, data analyses, and interpretations.Semantic proximity Read ↗

Mapping Genetic Architecture of Thousands of Complex Traits Using GWAS Summary StatisticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.