Article

The distribution of common-variant effect sizes

2020-09-20

Abstract excerpt

The genetic effect-size distribution describes the number of variants that affect disease risk and the range of their effect sizes. Accurate estimates of this distribution would provide insights into genetic architecture and set sample-size targets for future genome-wide association studies. We developed Fourier Mixture Regression (FMR) to estimate common-variant effect-size distributions from GWAS summary statist...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 840443bd-90aa-5388-8cc3-a63059bf1b9c
DOI: 10.1101/2020.09.19.304097

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The distribution of common-variant effect sizesDOI 10.1101/2020.09.19.304097Read

The distribution of common-variant effect sizes.Semantic proximity Read

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits.Semantic proximity Read

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits and implications for the futureSemantic proximity Read

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architectureSemantic proximity Read

Chapter 11: Genome-wide association studies.Semantic proximity Read

Phenome-wide heritability analysis of the UK Biobank.Semantic proximity Read

Genome-Wide Association Studies.Semantic proximity Read

An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies.Semantic proximity Read

Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model.Semantic proximity Read

What can genome-wide association studies tell us about the genetics of common disease?Semantic proximity Read

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.Semantic proximity Read

A generalized linear mixed model association tool for biobank-scale data.Semantic proximity Read