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Non-overlapping requirements of ASNA-1 function for insulin secretion, cisplatin resilience, and growth revealed by genetic analysis of point mutants in <i>C. elegans</i>

2022-07-12

Abstract excerpt

<h4>ABSTRACT</h4> ASNA1 plays an essential role in cisplatin chemotherapy response, type 2 diabetes, and heart disease. It is also an important biomarker in the treatment response of many diseases. Biochemically, ASNA1 has two mutually exclusive redox modulated roles: a tail-anchored protein (TAP) targeting function in the reduced state and a holdase/chaperone function in the oxidized state. Assigning biochemical...

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Literature Corpus work
9d02b7eb-2e96-586a-91d1-8cabfbcdd03d
DOI
10.1101/2022.07.12.499739
Open publication

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Non-overlapping requirements of ASNA-1 function for insulin secretion, cisplatin resilience, and growth revealed by genetic analysis of point mutants in <i>C. elegans</i>DOI 10.1101/2022.07.12.499739
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