Article

Decoding GNAO1 Mutations Using <em>Caenorhabditis elegans</em> Model System: Past Approaches and Future Prospectives

2024-10-31

Abstract excerpt

GNAO1 encephalopathies are a group of neglected genetic disorders primarily occurring due to de-novo point mutations in the Gαo protein-encoding gene in human GNAO1. This gene is reported to be highly conserved among Caenorhabditis elegans (C. elegans) and humans, with a sequence similarity of nearly 80%. Signaling pathways involved in various neurotransmitters, including GPCR pathways can be easily studied in the...

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Literature Corpus work: cf83b15c-fd11-5072-8338-13b94eff5caf
DOI: 10.20944/preprints202410.2524.v1

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