Article

Natural variation in <i>C. elegans</i> arsenic toxicity is explained by differences in branched chain amino acid metabolism

2018-07-22

Abstract excerpt

We find that variation in the dbt-1 gene underlies natural differences in Caenorhabditis elegans responses to the toxin arsenic. This gene encodes the E2 subunit of the branched-chain α-keto acid dehydrogenase (BCKDH) complex, a core component of branched-chain amino acid (BCAA) metabolism. We causally linked a non-synonymous variant in the conserved lipoyl domain of DBT-1 to differential arsenic responses. Usin...

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Literature Corpus work: 621c58b3-bf8c-5b2e-94b0-12deda172972
DOI: 10.1101/373787

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