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The <i>O</i> -GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress

2020-05-01

Abstract excerpt

The conserved O -GlcNAc transferase OGT O -GlcNAcylates serine and threonine residues of intracellular proteins to regulate their function. OGT is required for viability in mammalian cells, but its specific roles in cellular physiology are poorly understood. Here we describe a conserved requirement for OGT in an essential aspect of cell physiology: the hypertonic stress response. Through a forward genetic screen...

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Literature Corpus work
9b282a65-ce8a-5348-93d1-63f86eb6b779
DOI
10.1101/2020.05.01.072033
Open publication

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