Article

Astrocytes control motor neuronal mitochondrial axonal transport deficits in C9ORF72 ALS

2025-06-15

Abstract excerpt

Disrupted axonal transport and astrocyte dysfunction are implicated in amyotrophic lateral sclerosis (ALS). Here, we show these are intrinsically linked: human induced pluripotent stem cell-derived astrocytes carrying the C9ORF72 mutation disrupt axonal transport and mitochondrial function in motor neurons (MNs). Conversely, either isogenic gene-corrected astrocytes or selectively boosting C9ORF72-astrocyte mitoch...

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Identifiers and source

Literature Corpus work: 9cdc864a-c263-554c-bfb7-13d0afd75c06
DOI: 10.1101/2025.06.10.658820

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