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Article

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons.

Nature biotechnology - 10 Aug 2011

Haidet-Phillips Amanda M, Hester Mark E, Miranda Carlos J, Meyer Kathrin, Braun Lyndsey, Frakes Ashley, Song SungWon, Likhite Shibi, Murtha Matthew J, Foust Kevin D, Rao Meghan, Eagle Amy, Kammesheidt Anja, Christensen Ashley, Mendell Jerry R, Burghes Arthur H M, Kaspar Brian K

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease, with astrocytes implicated as contributing substantially to motor neuron death in familial (F)ALS. However, the proposed role of astrocytes in the pathology of ALS derives in part from rodent models of FALS based upon dominant mutations within the superoxide dismutase 1 (SOD1) gene, which account for <2% of all ALS cases. Their role in sporadic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21832997
DOI: 10.1038/nbt.1957
PMCID: PMC3170425

Genes

SOD1

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