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Astrocyte dysfunction distinguishes monozygotic twin <i>C9orf72</i> expansion carriers discordant for amyotrophic lateral sclerosis

2026-07-20

Abstract excerpt

Hexanucleotide repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis, yet many carriers remain asymptomatic for decades or never develop disease. This incomplete penetrance suggests that phenoconversion from genetic susceptibility to symptomatic disease onset is governed by epigenetic, environmental and cell-intrinsic modifiers. Astrocytes are key mediators of non-cell-au...

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Literature Corpus work
9376b408-cf47-5e3f-8137-0fec94263c7a
DOI
10.64898/2026.07.15.738192
Open publication

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Astrocyte dysfunction distinguishes monozygotic twin <i>C9orf72</i> expansion carriers discordant for amyotrophic lateral sclerosisDOI 10.64898/2026.07.15.738192
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