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Article

Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology.

Glia - 1 May 2020

Zhao Chen, Devlin Anna-Claire, Chouhan Amit K, Selvaraj Bhuvaneish T, Stavrou Maria, Burr Karen, Brivio Veronica, He Xin, Mehta Arpan R, Story David, Shaw Christopher E, Dando Owen, Hardingham Giles E, Miles Gareth B, Chandran Siddharthan

Abstract excerpt

Mutations in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS). Accumulating evidence implicates astrocytes as important non-cell autonomous contributors to ALS pathogenesis, although the potential deleterious effects of astrocytes on the function of motor neurons remains to be determined in a completely humanized model of C9orf72-mediated ALS. Here, we use a human iPSC-based model...

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Identifiers

PMID: 31841614
DOI: 10.1002/glia.23761
PMCID: PMC7078830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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