Article
Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation.
International journal of biological sciences - 1 Jan 2024
Liang Kristina Xiao, Chen Anbin, Kianian Atefeh, Kristiansen Cecilie Katrin, Yangzom Tsering, Furriol Jessica, Høyland Lena Elise, Ziegler Mathias, Kråkenes Torbjørn, Tzoulis Charalampos, Fang Evandro Fei, Sullivan Gareth John, Bindoff Laurence A
Abstract excerpt
Mitochondrial diseases are associated with neuronal death and mtDNA depletion. Astrocytes respond to injury or stimuli and damage to the central nervous system. Neurodegeneration can cause astrocytes to activate and acquire toxic functions that induce neuronal death. However, astrocyte activation and its impact on neuronal homeostasis in mitochondrial disease remain to be explored. Using patient cells carrying...
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