Article
Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity.
EBioMedicine - 1 Dec 2019
Birger Anastasya, Ben-Dor Israel, Ottolenghi Miri, Turetsky Tikva, Gil Yaniv, Sweetat Sahar, Perez Liat, Belzer Vitali, Casden Natania, Steiner Debora, Izrael Michal, Galun Eithan, Feldman Eva, Behar Oded, Reubinoff Benjamin
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons (MNs). It was shown that human astrocytes with mutations in genes associated with ALS, like C9orf72 (C9) or SOD1, reduce survival of MNs. Astrocyte toxicity may be related to their dysfunction or the release of neurotoxic factors. METHODS: We used human induced pluripotent stem cell-derived...
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