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Article

Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation

30 Mar 2021

Abstract excerpt

Abstract The principal hallmark of Parkinson’s disease (PD) is the selective neurodegeneration of dopaminergic neurones. Mounting evidence suggests that astrocytes may contribute to dopaminergic neurodegeneration through decreased homoeostatic support and deficient neuroprotection. In this study, we generated induced pluripotent stem cells (iPSC)-derived astrocytes from PD patients with LRRK2 (G2019S) mutation...

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PMID: 33785762
DOI: 10.1038/s41531-021-00175-w

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