Article

Rapid generation of ventral spinal cord-like astrocytes from human iPSCs for modeling non-cell autonomous mechanisms of lower motor neuron disease

2021-12-13

Abstract excerpt

Astrocytes play important roles in the function and survival of neuronal cells. Dysfunctions of astrocytes are associated with numerous disorders and diseases of the nervous system, including motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Human induced pluripotent stem cell (iPSC)-based approaches are becoming increasingly important for the study of the mechanisms underlying the involvement of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bc7bc277-c534-5f8a-9080-7f022b827460
DOI: 10.1101/2021.12.13.472474

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapid generation of ventral spinal cord-like astrocytes from human iPSCs for modeling non-cell autonomous mechanisms of lower motor neuron diseaseDOI 10.1101/2021.12.13.472474Read

Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discoverySemantic proximity Read

Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology.Semantic proximity Read

Generation of functional iPSC-derived astrocytes to model the neurodevelopmental disorder, Rett SyndromeSemantic proximity Read

Rapid specification of human pluripotent stem cells to functional astrocytesSemantic proximity Read

Varicose-projection astrocytes: a reactive phenotype associated with neuropathologySemantic proximity Read

Navigating Human Astrocyte Differentiation: Direct and Rapid one-step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network developmentSemantic proximity Read

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS.Semantic proximity Read

An efficient platform for astrocyte differentiation from human induced pluripotent stem cellsSemantic proximity Read

An update on human astrocytes and their role in development and diseaseSemantic proximity Read

Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cellsSemantic proximity Read

Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.Semantic proximity Read

When glia meet induced pluripotent stem cells (iPSCs).Semantic proximity Read