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Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo

30 Mar 2017

Abstract excerpt

Astrocytes from familial amyotrophic lateral sclerosis (ALS) patients or transgenic mice are toxic specifically to motor neurons (MNs). It is not known if astrocytes from sporadic ALS (sALS) patients cause MN degeneration in vivo and whether the effect is specific to MNs. By transplanting spinal neural progenitors, derived from sALS and healthy induced pluripotent stem cells (iPSCs), into the cervical spinal cord...

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PMID: 28366455
DOI: 10.1016/j.stemcr.2017.03.003

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