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Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs

2 Aug 2019

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a complex and fatal neurodegenerative disease for which the causes of disease onset and progression remain unclear. Recent advances in human induced pluripotent stem cell (hiPSC)-based models permit the study of the genetic factors associated with ALS in patient-derived neural cell types, including motor neurons and glia. While astrocyte dysfunction has traditionally been...

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PMID: 31381978
DOI: 10.1016/j.nbd.2019.104562

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