Article

Single-molecule analysis of purified proteins and nuclear extracts: insights from 8-oxoguanine glycosylase 1

2023-11-02

Abstract excerpt

By observing one molecule at a time, single-molecule studies can offer detailed insights about biomolecular processes including on rates, off rates, and diffusivity of molecules on strands of DNA. A recent technological advance (Single-molecule Analysis of DNA-binding proteins from Nuclear Extracts, SMADNE) has lowered the barrier to entry for single-molecule studies, and single-molecule dynamics can now be determ...

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Literature Corpus work: 9cc33c9d-f3ba-5904-94d2-190e7f1c31c9
DOI: 10.1101/2023.11.01.565178

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