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Local Chromatin Organization and Net Charge Modulate DNA Glycosylase Efficiency in Live Cells

2025-10-22

Abstract excerpt

<title>Abstract</title> <p>Diffusion governs molecular encounter rates and underpins the efficiency of chemical reactions, including those catalyzed by enzymes in crowded cellular environments. In the context of DNA repair, how local nuclear organization modulates enzymatic search efficiency remains poorly understood. Here, we apply spatially resolved single-molecule diffusivity mapping to investigate the dynamic...

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Literature Corpus work
57ba1e0d-2153-5e6f-a70b-8b0f54093e1a
DOI
10.21203/rs.3.rs-6816177/v1
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Local Chromatin Organization and Net Charge Modulate DNA Glycosylase Efficiency in Live CellsDOI 10.21203/rs.3.rs-6816177/v1
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