Article
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin.
Nucleic acids research - 11 Jan 2021
Bacolla Albino, Sengupta Shiladitya, Ye Zu, Yang Chunying, Mitra Joy, De-Paula Ruth B, Hegde Muralidhar L, Ahmed Zamal, Mort Matthew, Cooper David N, Mitra Sankar, Tainer John A
Abstract excerpt
Human genome stability requires efficient repair of oxidized bases, which is initiated via damage recognition and excision by NEIL1 and other base excision repair (BER) pathway DNA glycosylases (DGs). However, the biological mechanisms underlying detection of damaged bases among the million-fold excess of undamaged bases remain enigmatic. Indeed, mutation rates vary greatly within individual genomes, and lesion...
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