Article

Distinct genetic architecture of gene and isoform level QTL in the Diversity Outbred (DO) mouse population

2026-03-10

Abstract excerpt

Genetic association studies of mRNA abundance phenotypes link regulatory gene loci to mRNA abundance (quantitative trait loci; QTL). The majority of eQTL studies are limited to gene-level mRNAs and have not focused on mRNA isoforms. Here, we utilized a large, genetically diverse mouse population to map QTL for both gene and transcript isoform abundance. We identified largely overlapping sets of locally regulated m...

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Literature Corpus work: 9c9d0389-82a5-58f4-be97-f7e0341e1d3b
DOI: 10.64898/2026.03.06.710203

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