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Article

Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression.

Genome research - 1 Jun 2022

St Pierre Celine L, Macias-Velasco Juan F, Wayhart Jessica P, Yin Li, Semenkovich Clay F, Lawson Heather A

Abstract excerpt

Allele-specific expression (ASE) is a phenomenon in which one allele is preferentially expressed over the other. Genetic and epigenetic factors cause ASE by altering the final composition of a gene's product, leading to expression imbalances that can have functional consequences on phenotypes. Environmental signals also impact allele-specific expression, but how they contribute to this cross talk remains...

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Share to Alleles
Share to Dietary Fats
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 35501130
DOI: 10.1101/gr.276193.121
PMCID: PMC9248887

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