Article
Defining the consequences of genetic variation on a proteome-wide scale.
Nature - 23 Jun 2016
Chick Joel M, Munger Steven C, Simecek Petr, Huttlin Edward L, Choi Kwangbom, Gatti Daniel M, Raghupathy Narayanan, Svenson Karen L, Churchill Gary A, Gygi Steven P
Abstract excerpt
Genetic variation modulates protein expression through both transcriptional and post-transcriptional mechanisms. To characterize the consequences of natural genetic diversity on the proteome, here we combine a multiplexed, mass spectrometry-based method for protein quantification with an emerging outbred mouse model containing extensive genetic variation from eight inbred founder strains. By measuring genome-wide...
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