Article
High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues.
Genome research - 1 Jun 2009
Huang Guo-Jen, Shifman Sagiv, Valdar William, Johannesson Martina, Yalcin Binnaz, Taylor Martin S, Taylor Jennifer M, Mott Richard, Flint Jonathan
Abstract excerpt
A proportion of the genetic variants underlying complex phenotypes do so through their effects on gene expression, so an important challenge in complex trait analysis is to discover the genetic basis for the variation in transcript abundance. So far, the potential of mapping both quantitative trait loci (QTLs) and expression quantitative trait loci (eQTLs) in rodents has been limited by the low mapping resolution...
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