Comparative analysis of proteome and transcriptome variation in mouse.

doi:10.1371/journal.pgen.1001393

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Article

Comparative analysis of proteome and transcriptome variation in mouse.

PLoS genetics - 1 Jun 2011

Ghazalpour Anatole, Bennett Brian, Petyuk Vladislav A, Orozco Luz, Hagopian Raffi, Mungrue Imran N, Farber Charles R, Sinsheimer Janet, Kang Hyun M, Furlotte Nicholas, Park Christopher C, Wen Ping-Zi, Brewer Heather, Weitz Karl, Camp David G, Pan Calvin, Yordanova Roumyana, Neuhaus Isaac, Tilford Charles, Siemers Nathan, Gargalovic Peter, Eskin Eleazar, Kirchgessner Todd, Smith Desmond J, Smith Richard D, Lusis Aldons J

Abstract excerpt

The relationships between the levels of transcripts and the levels of the proteins they encode have not been examined comprehensively in mammals, although previous work in plants and yeast suggest a surprisingly modest correlation. We have examined this issue using a genetic approach in which natural variations were used to perturb both transcript levels and protein levels among inbred strains of mice. We...

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PMID: 21695224
DOI: 10.1371/journal.pgen.1001393
PMCID: PMC3111477

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